• Nominations open for the 11th Awards term The Sheikh Hamdan bin Rashid Al Maktoum Award for Medical Sciences announces the topics for the 11th Award term: AI in Healthcare, Genomics, Diagnostics and Therapeutics.
  • The 11th Dubai International Conference for Medical Sciences (DICMS) The Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences announces the 11th Dubai International Conference for Medical Sciences, held in conjunction with the Award ceremony on 24-27 November, 2020 in Dubai, United Arab Emirates.
  • Hamdan bin Rashid receives Delegation from the Islamic Organization for Medical SciencesH.H. Sheikh Hamdan bin Rashid Al Maktoum, Deputy Ruler of Dubai and Minister of Finance, today received, in his palace in Zabeel, a delegation from the Islamic Organization for Med ...
  • Hamdan bin Rashid receives ISESCO Director-GeneralH.H. Sheikh Hamdan bin Rashid Al Maktoum, Deputy Ruler of Dubai and Minister of Finance, discussed the activities and development programmes carried out by the Islamic World Educat ...
  • The 8th Pan Arab Human Genetics Conference Concludes in DubaiThe largest gathering of geneticists and researchers in the Arab world, the 8th Pan Arab Human Genetics Conference concluded its events today.

Prof. Sehamuddin Galadari & Team

UAE Awards

Hamdan Award for Original Research Paper Published in Hamdan Medical Journal
2017-2018

Professor Sehamuddin Galadari& his team
Siraj Pallichankandy, Anees Rahman, Faisal Thayyullathil
Cell Signalling Laboratory, Department of Biochemistry
College of Medicine and Health Sciences
United Arab Emirates University
United Arab Emirate.

Malignant glioma is the most common primary tumor of the central nervous system and the most lethal among all cancers. The current standard treatments for the management of malignant Gliomas include surgical resection, radiation therapy and chemotherapy.
 
Gliomas are known to be resistant to therapies that induce apoptosis but some evidences indicate that glioblastoma cells may be less resistant to therapies that induce autophagy. In fact the autophagic cell death pathway is being explored and is a promising avenue for further therapeutic development.
The FTY720, a novel sphingosine analogue,  is an immunosuppressant and is the first US- FDA approved oral drug for the treatment of multiple sclerosis. In addition to the immunosuppression effect, FTY720 has also been shown to induce apoptotic cell death in a wide variety of cancers and autophagic cell death in ovarian cancer.
 
This study investigates the antitumor potential of FTY720 and it discloses the molecular mechanism of its cytotoxic effects on malignant glioma cells

 

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